(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) 是一种 Substance P 类似物，在大鼠大脑中对神经激肽 1 受体 (NK1R) 的作用与 Substance P 大致相等，但作用时间大大延长。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 能选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 还可增加大鼠运动活性，诱导成瘾剂寻求行为的恢复。

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P analogue that has approximately the same effects as Substance P on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

[Glp5, (Me)Phe8,Sar9] Substance P (5-11) (注入腹侧被盖区；2 μg/侧；单次) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢。[Glp5, (Me)Phe8,Sar9] Substance P (5-11) (注入腹侧被盖区；0.5、1.5、3 μg/侧；单次) 增加大鼠运动活性，诱导成瘾剂寻求行为的恢复。Animal Model:Male Sprague-Dawley rats (300-350 g).Dosage:2 μg/side Administration:Inject into the ventral tegmental area; single Result:Selectively activated mesolimbic and mesocortical dopamine metabolism.Animal Model:Male Wistar rats (300-350 g).Dosage:0.5, 1.5, 3 μg/side Administration:Inject into the ventral tegmental area; single Result:Significantly increased locomotor activity when at 3 μg/side.

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Others

Other Targets

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77128-69-9

880.06

C43H61N9O9S

>98% (HPLC)

DMSO : ≥ 100 mg/mL (113.63 mM; )

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(-20℃)

With Ice Pack

≥ 2 years